HETEROGENEOUS TARGETABLE HER2/BRCA/ER · Sortable Machinery HER2 amp / BRCA1/2 / ER+ / TNBC γ₁ = 14.134725141734693 · BREAST · HER2 · ER+ · CDK4/6i · BRCA1/2 · immunot CANCER BOARD NEURO
BREAST · HER2+ / TNBC
Driver
HER2 amp / BRCA1/2 / ER+ / TNBC
Coverage
~130/100k · Most survivable with treatment
Confidence
PROVEN
Open Sorries
⚠ TNBC limited targeted options
⚠ Brain metastasis in HER2+
⚠ CDK4/6 resistance
HYPOTHESIS
HER2+ → trastuzumab/pertuzumab/T-DXd. BRCA → PARP inhibitors. TNBC → immuno-chemo.
⚠ OPEN: TNBC CNS metastasis — BBB penetration + immuno combo
3Sorries
γ₁14.134725141734693
CATAN CANCER · BREAST-HER2